SIRPB2 Antibody (1008702) [Alexa Fluor® 488]


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Product Details

Reactivity HuSpecies Glossary
Applications Flow
Alexa Fluor 488

SIRPB2 Antibody (1008702) [Alexa Fluor® 488] Summary

HEK293 human embryonic kidney cell line, HEK293 derived Human SIRP beta 2
Accession # Q5JXA9
Detects human SIRP beta 2 in direct ELISAs.
Purity Statement
Protein A or G purified from hybridoma culture supernatant
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  • Flow Cytometry 0.25-1 ug/10^6 cells

Packaging, Storage & Formulations

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SIRPB2 Antibody (1008702) [Alexa Fluor® 488]

  • dJ776F14.2
  • Protein Tyrosine Phosphatase Non-Receptor Type Substrate 1-Like 3
  • Protein Tyrosine Phosphatase Non-Receptor Type Substrate Protein
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1-Like
  • Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1-Like 3
  • PTPN1L
  • PTPNS1L3
  • Signal-Regulatory Protein Beta 2
  • Signal-Regulatory Protein Beta-2
  • SIRP beta 2
  • SIRP-beta-2


Signal-regulatory protein beta-2(SIRP-beta-2), is a ~37 kDa monomeric single pass type I membrane glycoprotein. It belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily (1). The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions (1). SIRP-beta-2 contains an N-terminal signal peptide (aa1-32), two extracellular Ig-like domains: a V-type 1 (aa 33-143) and a V-type 2 (aa 157-258) containing three potential N-linked glycosylation sites, a helical transmembrane domain (aa 288-308), and a cytoplasmic domain (aa 309-342) (1). A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) (2). Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages (3). Based on expression patterns, SIRPs are thought to have roles in immune regulation (4). SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation (5, 6). There are currently no known mouse or rat homologs for this protein.
  1. van Beek, E.M. et al. (2005) J. Immunol. 175:7781.
  2. Liu, Y. et al. (2005) Journal of Biological Chemistry. 280:36132.
  3. Matozaki, T. et al. (2009) Trends in Cell Biology. 19:72.
  4. Barclay A.N. et al. (2006) Nat Rev Immunol. 6:457.
  5. Barclay A.N. et al. (2014) Annu Rev Immunol. 32:25.
  6. Veillette A. (2018) Trends Immunol. 39:173.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB99981U
Alexa Fluor 405 FAB99981V
Alexa Fluor 488 FAB99981G
Alexa Fluor 594 FAB99981T
Alexa Fluor 647 FAB99981R
Alexa Fluor 700 FAB99981N
Alexa Fluor 750 FAB99981S

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