SHANK1 Antibody [DyLight 594]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 594

SHANK1 Antibody [DyLight 594] Summary

• Immunogen: A synthetic peptide made to an N terminal portion of human SHANK1 protein (between residues 110-160) [UniProt Q9Y566]
• Localization: Cytoplasmic, Cell junction, Postsynaptic density of neuronal cells.
• Marker: TGN Marker
• Specificity: Reacts with residues [ERLLREYPQSFEKGV] of the N terminus of the rat Shank1a protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SHANK1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Reacts with human and rat Shank1a. Does not react with mouse Shank1a.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for SHANK1 Antibody [DyLight 594]

• SH3 and multiple ankyrin repeat domains 1
• SH3 and multiple ankyrin repeat domains protein 1
• Shank1
• Somatostatin receptor-interacting protein
• SSTR-interacting protein
• SSTRIPSPANK-1
• synamon

Background

Shank is a novel family of postsynaptic density proteins (PSD) that bind to PSD-95-associated protein GKAP. Its putative function is to act as a scaffold protein in the PSD to cross-link NMDA receptors/PSD-95 complexes and couple them to regulators of the actin cytoskeleton. Shank1a is a splice variant of Shank1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SHANK1