SCP1 Antibody [DyLight 405]

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Product Details

Summary
Reactivity Hu, Mu, Rt, PmSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 405

SCP1 Antibody [DyLight 405] Summary

Immunogen
A C-terminal synthetic peptide made to the human SCP1 protein sequence. [UniProt# Q15431]
Localization
Nuclear
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SYCP1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
Application Notes
This SCP1 antibody is useful for Immunocytochemistry/Immunofluorescence. It does not appear to work in Immunohistochemistry on paraffin-embedded sections. Use in Western Blot was reported in scientific literature (PMID: 23843895). *The investigator should determine the optimal working dilution for a specific application.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SCP1 Antibody [DyLight 405]

  • Cancer/testis antigen 8
  • CT8MGC104417
  • HOM-TES-14
  • SCP1SCP-1
  • synaptonemal complex protein 1

Background

SCP1 (synaptonemal complex protein 1), also called cancer/testis antigen 8 (CT8), belongs to a growing family of cancer/testis antigens (CTA) which includes several proteins (MAGE, GAGE/PAGE/XAGE, NY-ESO-1/LAGE-1, SSX, SPANX, TRAG-3, BAGE, OY-TES-1, CT17, NY-BR-3 and SCP-1) that are not expressed in normal tissues except for testis and, in some cases, placenta. SCP1 is found in a complex with SYCE1 and SYCE2, and is a major component of the transverse filaments of synaptonemal complexes. SCP-1 is established to be expressed selectively during the meiotic prophase of spermatocytes formation and is involved in the pairing of homologous chromosomes during meiosis I. SCP1 is localized in tripartite segments of synaptonemal complexes, between lateral elements in the nucleus, and is found only where the chromosome cores are synapsed. Its N-terminus is found towards the center, whereas, the C-terminus extends well into the lateral domain of the synaptonemal complex. SCP-1 differs from other members of CTA family by its localization on chromosome 1 and it is frequently observed to have variable expression in neoplastic tissues/cell lines including malignant gliomas, breast, renal cell, ovarian, pancreatic and hepatocellular carcinomas. Because of exclusive expression of SCP1 in testis/placenta, it is emerging as an important target for cancer research and therapy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for SCP1 Antibody (NB300-228V) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for SCP1 Antibody (NB300-228V)

Discover related pathways, diseases and genes to SCP1 Antibody (NB300-228V). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on SCP1.

Using SCP3/SYCP3 Antibodies as Meiosis Markers in Gametogenesis and DNA Repair Studies
The synaptonemal complex (SC) is a protein structure that forms during the synapsis of homologous chromosomes during meiosis. This structure is involved in the processes of chromosome synapsis, genetic recombination and subsequent chromosome segregati...  Read full blog post.

SCP1 a Potential Cancer Target for Immunotherapy
Synaptonemal Complex Protein 1 (SCP1) is a novel tumor antigen that belongs to the growing family of cancer/testis antigens (CTA). SCP-1 is known to be selectively expressed during the meiotic prophase of spermatocytes and is involved in the pairing o...  Read full blog post.

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Bioinformatics

Gene Symbol SYCP1