SCIMP Antibody (NVL-07)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, ICC/IF, IP, CyTOF-ready
Clone
NVL-07
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

SCIMP Antibody (NVL-07) Summary

Immunogen
Recombinant intracellular part of human SCIMP.
Specificity
The mouse monoclonal antibody NVL-07 recognizes intracellular part of human transmembrane adaptor SCIMP. This protein of 17 kDa predicted Mw migrates as a 22 kDa band on SDS PAGE.
Isotype
IgG2 Alpha
Clonality
Monoclonal
Host
Mouse
Gene
SCIMP
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
  • Immunoprecipitation 1:10-1:500
  • CyTOF-ready
Application Notes
Purity: > 95% by SDS-PAGE, Flow Cytometry - intracellular staining.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for SCIMP Antibody (NVL-07)

  • transmembrane protein C17orf87
  • C17orf87
  • chromosome 17 open reading frame 87
  • DTFT5783
  • FLJ32580
  • SLP adapter and CSK-interacting membrane protein
  • SLP adaptor and CSK interacting membrane protein
  • SLP65/SLP76, Csk-interacting membrane protein
  • UNQ5783

Background

SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for SCIMP Antibody (NBP2-22349) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP2-22349AF405
Alexa Fluor 488 Labeled NBP2-22349AF488
Alexa Fluor 647 Labeled NBP2-22349AF647
Alexa Fluor 700 Labeled NBP2-22349AF700
Allophycocyanin Labeled NBP2-22349APC
DyLight 350 Labeled NBP2-22349UV
DyLight 405 Labeled NBP2-22349V
DyLight 488 Labeled NBP2-22349G
DyLight 680 Labeled NBP2-22349FR
DyLight 755 Labeled NBP2-22349IR
PE Labeled NBP2-22349PE
PerCP Labeled NBP2-22349PCP

Additional SCIMP Products

SCIMP NBP2-22349

Bioinformatics Tool for SCIMP Antibody (NBP2-22349)

Discover related pathways, diseases and genes to SCIMP Antibody (NBP2-22349). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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PTMs for SCIMP Antibody (NBP2-22349)

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Blogs on SCIMP

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Calculators

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Bioinformatics

Gene Symbol SCIMP
Uniprot