SCIMP Products

Description

SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.

Bioinformatics

Uniprot	Q6UWF3 Human
Product By Gene ID	388325
Alternate Names	transmembrane protein C17orf87 C17orf87 chromosome 17 open reading frame 87 DTFT5783 FLJ32580 SLP adapter and CSK-interacting membrane protein SLP adaptor and CSK interacting membrane protein SLP65/SLP76, Csk-interacting membrane protein UNQ5783