Ryanodine Receptor 2 Antibody

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Immunohistochemistry-Paraffin: Ryanodine Receptor 2 Antibody [NBP1-61409] - Analysis of paraffin-embedded human brain tissue, using Ryanodine Receptor 2 Antibody. The picture on the right is treated with the ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications ELISA, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Ryanodine Receptor 2 Antibody Summary

Immunogen
The antiserum was produced against synthesized peptide derived from human RyR2. The immunogen region is: Internal.
Specificity
RyR2 (Ab-2808) Antibody detects endogenous levels of total RyR2 protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RYR2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • ELISA 1:1000
  • Immunohistochemistry 1:50-1:100
  • Immunohistochemistry-Paraffin 1:50-1:100

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (without Mg2+ and Ca2+, pH 7.4), 0.15M NaCl and 50% Glycerol
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Ryanodine Receptor 2 Antibody

  • ARVC2arrhythmogenic right ventricular dysplasia 2
  • ARVD2
  • Cardiac muscle-type ryanodine receptor
  • hRYR-2
  • ryanodine receptor 2 (cardiac)
  • ryanodine receptor 2
  • RyR2
  • RYR-2
  • VTSIPCardiac muscle ryanodine receptor-calcium release channel

Background

Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are two key components of the intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca2+ from internal stores. The alpha1-subunit of the DHPR contains a cytoplasmic loop which is thought to be involved in the interactions with RyR. Phosphorylation of the DHPR alpha1-subunit is also thought to play a role in the functional interaction of DHPR and RyR. Mutation in DHPR alpha1 results in excitation-contraction uncoupling, leading to muscular dysgenesis, a complete inactivity in developing skeletal muscles. Cells that do not express RyR also lack excitation-contraction coupling and exhibit a severalfold reduction in Ca2+ current density.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol RYR2
Uniprot