Ryanodine Receptor 2 Products

Antibodies
Ryanodine Receptor 2 Antibody ...
Ryanodine Receptor 2 Antibody
NBP1-90091
Species: Hu, Mouse, Rat
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Ryanodine Receptor 2 Antibody ...
Ryanodine Receptor 2 Antibody
NBP1-61409
Species: Hu, Mu, Rt
Applications: ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
Ryanodine Receptor 2 Recombin ...
Ryanodine Receptor 2 Recombinant P...
NBP1-90091PEP
Species: Hu
Applications: AC

Description

Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are two key components of the intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca2+ from internal stores. The alpha1-subunit of the DHPR contains a cytoplasmic loop which is thought to be involved in the interactions with RyR. Phosphorylation of the DHPR alpha1-subunit is also thought to play a role in the functional interaction of DHPR and RyR. Mutation in DHPR alpha1 results in excitation-contraction uncoupling, leading to muscular dysgenesis, a complete inactivity in developing skeletal muscles. Cells that do not express RyR also lack excitation-contraction coupling and exhibit a severalfold reduction in Ca2+ current density.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Product By Gene ID 6262
Alternate Names
  • Cardiac muscle-type ryanodine receptor
  • hRYR-2
  • RyR2
  • RYR-2
  • ryanodine receptor 2
  • VTSIPCardiac muscle ryanodine receptor-calcium release channel
  • ARVC2arrhythmogenic right ventricular dysplasia 2
  • ARVD2
  • ryanodine receptor 2 (cardiac)

PTMs for Ryanodine Receptor 2

Learn more about PTMs related to Ryanodine Receptor 2.

Phosphorylation
Cleavage
Dephosphorylation

Bioinformatics Tool for Ryanodine Receptor 2

Discover related pathways, diseases and genes to Ryanodine Receptor 2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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