RSK4 Antibody (374521) [Janelia Fluor® 669]

• Reactivity: Hu
• Applications: WB
• Clone: 374521
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Janelia Fluor 669

RSK4 Antibody (374521) [Janelia Fluor® 669] Summary

• Immunogen: E. coli-derived recombinant human RSK4
  Met1-Leu745
  Accession # Q9UK32
• Specificity: Detects human RSK4 in Western blots. In Western blots, no cross-reactivity with recombinant human (rh) RSK1, rhRSK2, or rhRSK3 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: RPS6KA6
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for RSK4 Antibody (374521) [Janelia Fluor® 669]

• EC 2.7.11
• EC 2.7.11.1
• p90-RSK 6
• p90RSK6
• pp90RSK4
• PP90RSK4,90 kDa ribosomal protein S6 kinase 6
• ribosomal protein S6 kinase alpha-6
• ribosomal protein S6 kinase, 90kDa, polypeptide 6
• Ribosomal S6 kinase 4
• RPS6KA6
• RSK4
• RSK-4
• RSK4ribosomal protein S6 kinase, 90kD, polypeptide 6
• S6K-alpha 6
• S6K-alpha-6

Background

RSK4 is a member of the family of 90-kDa ribosomal S6 kinases (1). These proteins are a class of serine/threonine kinases that are activated in response to various extracellular signals, including growth factors, polypeptide hormones and neurotransmitters (2). RSK4 is most abundantly expressed in brain and kidney. The predicted protein of 746 amino acids shows a high level of homology to three previously isolated members of the human RSK family. RSK2 is involved in Coffin-Lowry syndrome and nonspecific MRX. The localization of RSK4 in the interval that is commonly deleted in mentally retarded males together with the high degree of amino acid identity with RSK2 suggests that RSK4 plays a role in normal neuronal development (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RPS6KA6