Rit2 Antibody

Product Discontinued

Rit2 Antibody Summary

• Immunogen: Recombinant His-tagged human Rit2 protein
• Localization: Plasma membrane
• Specificity: Recognizes human recombinant and native Rit2 protein.Cross-reacts slightly with other Ras proteins.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RIT2
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Western Blot 5-10 ug/ml
• Theoretical MW: 25 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross-reacts with Human. Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.3)
• Preservative: 0.08% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: IgG purified

Alternate Names for Rit2 Antibody

• GTP-binding protein Rit2
• GTP-binding protein Roc2
• Ras-like protein expressed in neurons
• Ras-like without CAAX 2
• Ras-like without CAAX protein 2
• RIBA
• Ric (Drosophila)-like, expressed in neurons
• Ric-like, expressed in neurons
• RIN
• Rit2
• ROC2

Background

RIT2 is a gene that codes for a protein which binds and exchanges GTP and GDP, and has two isoforms with lengths of 217 and 153 amino acids, with weights of approximately 25 and 17 kDa, respectively. Current studies are being done on diseases and disorders relating to this gene including neuronitis, ehrlichiosis, cryoglobulinemia, hepatitis, Parkinson's disease, and schizophrenia. RIT2 has been shown to have interactions with CALM1, CALM2, CALM3, RLF, and HRAS in pathways such as the Trk receptor signaling, signaling to NGF, and signaling to ERKs pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RIT2
• Entrez:
  • 6014(Human)
• Uniprot:
  • Q99578(Human)