Recombinant Mouse IL-1Rrp2/IL-1R6 Protein

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Binding Activity

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Recombinant Mouse IL-1Rrp2/IL-1R6 Protein Summary

Details of Functionality
Measured by its binding ability in a functional ELISA. Immobilized rmIL-1F5, rmIL-1F6, or rmIL-1F8 at 1 µg/mL (100 µL/well) can bind
rmIL-1 Rrp2/his with a linear range of 0.078-5 µg/mL.
Source
Mouse myeloma cell line, NS0-derived mouse IL-1 Rrp2/IL-1 R6 protein
Asp22-Arg338 (Ala158Val), with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Asp22
Protein/Peptide Type
Recombinant Proteins
Gene
Il1rl2
Purity
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Binding Activity
Theoretical MW
36.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
55-68 kDa, reducing conditions

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Purity
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-1Rrp2/IL-1R6 Protein

  • IL-1 R6
  • IL-1 Rrp2
  • IL1RL2
  • IL-1RL2
  • IL1Rrp2
  • IL-1Rrp2
  • IL1RRP2IL1R-rp2Interleukin-1 receptor-related protein 2
  • interleukin 1 receptor-like 2
  • interleukin-1 receptor-like 2

Background

IL-1 Rrp2, also known as IL-1 R6, is a member of the IL-1 R/TLR superfamily. Members of this superfamily have a characteristic Toll-IL-1 R (TIR) domain in their cytoplasmic region. This superfamily can be further divided into three subgroups based on extracellular region analogies. IL-1 Rrp2 belongs to Subgroup 1 which is characterized by the presence of at least one immunoglobulin-like domain (1). Mouse IL-1 Rrp2/IL-1R6 is a 70 kDa type I transmembrane glycoprotein that is synthesized as a 574 amino acid (aa) precursor. The precursor contains a 21 aa signal sequence, a 317 aa extracellular region, a 21 aa transmembrane segment, and a 215 aa cytoplasmic domain (2). The extracellular region contains three C-type Ig-like domains. Within the extracellular region, mouse IL-1 Rrp2 is 64% and 80% aa identical to human and rat IL-1 Rrp2, respectively. Expression of IL-1 Rrp2 is restricted to lung epithelium, monocytes, skin-derived keratinocytes, fibroblasts and, to a lesser extent, endothelial cells (3). Studies have demonstrated that the functional receptor for IL-1F6, IL-1F8 and IL-1F9 is a combination of IL-1 Rrp2 and IL-1 RAcP. This suggests that IL-1 Rrp2 ligands may signal in a similar fashion to IL-1 and IL-18. In each case, there is a binding receptor which, upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex (4).

  1. Dunne, A. and L.A. O’Neill, (2003) Sci. STKE Feb 25 (171):re3.
  2. Born, T.L. et al. (2000) J. Biol. Chem. 275:29946.
  3. Lovenberg, T.S. et al. (1996) J. Neuroimmunol. 70:113.
  4. Towne, J.E. et al. (2004) J. Biol. Chem. 279:13677.

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Bioinformatics

Gene Symbol Il1rl2
Uniprot