PTGER1 Antibody (998412) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: IHC
• Clone: 998412
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

PTGER1 Antibody (998412) [Alexa Fluor® 488] Summary

• Immunogen: Synthetic peptide containing human PTGER1
  Accession # P34995
• Specificity: Detects human PTGER1 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PTGER1 Antibody (998412) [Alexa Fluor® 488]

• EP1
• PGE receptor EP1 subtype
• PGE receptor, EP1 subtype
• PGE2 receptor EP1 subtype
• prostaglandin E receptor 1 (subtype EP1), 42kD
• prostaglandin E receptor 1 (subtype EP1), 42kDa
• prostaglandin E receptor 1, subtype EP1
• prostaglandin E2 receptor EP1 subtype
• Prostanoid EP1 receptor
• PTGER1

Background

Prostaglandin E2 Receptor 1/ PTGER1/EP1, a member of the G protein-coupled receptor family, is one of four receptors for Prostaglandin E2 (PGE2). Expression is highest in kidney and spleen, with very low expression in most other tissues. Stimulation of angiogenesis in primate ovulatory follicles by luteinizing hormone has been shown to be mediated by PGE2 through PTGER1 and PTGER2 receptors. In epidermis, E2 plays a role in keratinocyte differentiaton. Expression and function of EP1 in carcinomas has been studied. For example, cytoplasmic and nuclear localization of EP1 in breast cancer has been reported in association with prognostic markers. And activation of EP1 mediated by COX2 causes VEGFC upregulation in lung adenocarcinomas.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.