Proprotein Convertase 2/PCSK2 Antibody (RB18543)

Product Discontinued

Proprotein Convertase 2/PCSK2 Antibody (RB18543) Summary

• Immunogen: This PCSK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the N-terminal region of human PCSK2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PCSK2
• Purity: Ammonium sulfate precipitation

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:10 - 1:50
  • Immunocytochemistry/ Immunofluorescence 1:10 - 1:50
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:10 - 1:50
  • Western Blot 1:1000
• Theoretical MW: 70.565 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Predicted to react with Pig and Rat.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 2 mg/ml
• Purity: Ammonium sulfate precipitation

Alternate Names for Proprotein Convertase 2/PCSK2 Antibody (RB18543)

• EC 3.4.21
• EC 3.4.21.94
• KEX2-like endoprotease 2
• NEC 2
• NEC2
• NEC2SPC2
• neuroendocrine convertase 2
• PC2
• PC2NEC-2
• PCSK2
• Prohormone convertase 2
• Proprotein Convertase 2
• proprotein convertase subtilisin/kexin type 2
• SPC2

Background

PCSK2 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This protein is a proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. The protein is also known to cleave proopiomelanocortin, proenkephalin, prodynorphin and proluteinizing-hormone-releasing hormone.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PCSK2
• Uniprot:
  • P16519(Human)