Prohibitin 2 Antibody

Immunohistochemistry-Paraffin: Prohibitin 2 Antibody [NBP1-72016] - Staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Immunohistochemistry-Paraffin: Prohibitin 2 Antibody [NBP1-72016] - Staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Product Discontinued

Prohibitin 2 Antibody Summary

• Immunogen: KLH-conjugated synthetic peptide between amino acids 106-134 from human Prohibitin 2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PHB2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1:1000
• Application Notes: WB: Mouse only reactivity validation.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Purity: Protein A purified

Alternate Names for Prohibitin 2 Antibody

• BAP
• Bap37
• BCAP37
• B-cell associated protein
• D-Prohibitin
• MGC117268
• p22
• PHB2
• PNAS-141
• Prohibitin 2
• prohibitin-2
• REA
• REAB-cell receptor-associated protein BAP37
• Repressor of estrogen receptor activity

Background

PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). It functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. PHB2 competes with NCOA1 for modulation of ER transcriptional activity. It probably involved in regulating mitochondrial respiration activity and in aging.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PHB2
• Entrez:
  • 11331(Human)
• Uniprot:
  • Q99623()