Preso/FRMPD4 Antibody (809408) [Alexa Fluor® 532]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 809408
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

Preso/FRMPD4 Antibody (809408) [Alexa Fluor® 532] Summary

• Immunogen: E. coli-derived recombinant human Preso/FRMPD4
  Asn890-Ser1022
  Accession # Q14CM0
• Specificity: Detects human Preso/FRMPD4 in direct ELISAs and human and mouse Preso/FRMPD4 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Preso/FRMPD4 Antibody (809408) [Alexa Fluor® 532]

• FERM and PDZ domain containing 4
• FERM and PDZ domain-containing protein 4
• FRMPD4
• MGC142260
• MGC142262
• PDZ domain containing 10
• PDZD10
• PDZK10
• Preso

Background

Preso, also known as FRMPD4 and PDZD10, is a scaffolding protein that is widely expressed in the brain as 140 kDa and 170 kDa species. It contains one WW domain (aa 33-66) one PDZ domain (aa 78-155), and one FERM domain (aa 204-519). The 140 kDa species is enriched in post-synaptic densities where it interacts with PSD-95, SAP97, SAP102, and F-actin. Preso promotes dendritic spine extension and maintenance as well as excitatory synaptic transmission. Within aa 890-1022, human Preso shares approximately 94% aa sequence identity with mouse and rat Preso.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.