PP2C beta/PPM1B Antibody [mFluor Violet 450 SE]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: mFluor Violet 450 SE

PP2C beta/PPM1B Antibody [mFluor Violet 450 SE] Summary

• Immunogen: E. coli-derived recombinant human PP2C beta
  Met1-Gly378
  Accession # O75688
• Specificity: Detects endogenous human, mouse and rat PP2C beta in Western blots. In Western blots, this antibody does not cross‑react with recombinant human PP2C alpha or PP2Cδ.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: PPM1B
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for PP2C beta/PPM1B Antibody [mFluor Violet 450 SE]

• EC 3.1.3.16
• MGC21657
• PP2C beta
• Pp2c2
• PP2CB
• PP2C-beta
• PP2C-beta-X
• PP2CBmagnesium-dependent, beta isoform
• PPM1B
• protein phosphatase 1B
• Protein phosphatase 2C isoform beta
• protein phosphatase 2C-like protein
• protein phosphatase, Mg2+/Mn2+ dependent, 1B

Background

PPM1B is encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PPM1B