POU2F3 Antibody (1091214) [Alexa Fluor™ Plus 647]

• Clone: 1091214
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

POU2F3 Antibody (1091214) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects a synthetic peptide specific for human POU2F3 around amino acid 100 in Direct ELISA.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for POU2F3 Antibody (1091214) [Alexa Fluor™ Plus 647]

• Epoc-1
• MGC126698
• OCT11
• OCT-11
• OCT11FLJ40063
• Octamer-binding protein 11
• Octamer-binding transcription factor 11
• OTF11
• OTF-11
• PLA1
• PLA-1
• POU class 2 homeobox 3
• POU domain class 2, transcription factor 3
• POU domain, class 2, transcription factor 3
• POU transcription factor
• POU2F3
• Skn-1a
• Transcription factor PLA-1
• Transcription factor Skn-1

Background

POU2F3 is a 47 kDa transcription factor involved in the regulation of the differentiation of keratinocytes. It is also a part of the POU2F3-POU2AF2/POU2AF3 complex that drives the expression of tuft-cell-specific genes. Normal and neoplastic tuft cells share a genetic requirement for POU2F3. POU2F3 is utilized as an ancillary marker for the diagnosis of neuroendocrine-low small cell lung cancer. It is also positive in mesenchymal and neuroectodermal tumors including synovial carcinoma, solitary fibrous tumor, glioblastoma, Wilms tumor and melanoma.

1. Hildesheim J, Kühn U, Yee CL, Foster RA, Yancey KB, Vogel JC. The hSkn-1a POU transcription factor enhances epidermal stratification by promoting keratinocyte proliferation. J Cell Sci. 2001 May;114(Pt 10):1913-23. doi: 10.1242/jcs.114.10.1913. PMID: 11329378. 
2. Wu XS, He XY, Ipsaro JJ, Huang YH, Preall JB, Ng D, Shue YT, Sage J, Egeblad M, Joshua-Tor L, Vakoc CR. OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage. Nature. 2022 Jul;607(7917):169-175. doi: 10.1038/s41586-022-04842-7. Epub 2022 May 16. PMID: 35576971; PMCID: PMC9419707. 
3. Kaczorowski M, Ylaya K, Chłopek M, Lasota J, Miettinen M. Expression of POU2F3 Transcription Factor and POU2AF2, POU2F3 Coactivator, in Tuft Cell-like Carcinoma and Other Tumors. Am J Surg Pathol. 2024 Sep 25. doi: 10.1097/PAS.0000000000002313. Epub ahead of print. PMID: 39319626.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.