PHLPP Antibody

Product Discontinued

PHLPP Antibody Summary

• Immunogen: The immunogen this antibody was made to, maps to a region between residue 1175 to 1225 of human PH Domain and Leucine Rich Repeat Protein Phosphatase using the numbering given in entry NP_919431.1 (GeneID 23239).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PHLPP1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 2 - 10 ug/mg
  • Western Blot 1:2000 - 1:10000

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tris-Citrate/Phosphate (pH 7.0 - 8.0)
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PHLPP Antibody

• EC 3.1.3.16
• hSCOP
• KIAA0606
• MGC161555
• PH domain and leucine rich repeat protein phosphatase 1
• PH domain and leucine rich repeat protein phosphatase
• PH domain leucine-rich repeat-containing protein phosphatase 1
• PHLPP
• pleckstrin homology domain containing, family E (with leucine rich repeats)member 1
• Pleckstrin homology domain-containing family E member 1
• PLEKHE1
• SCN circadian oscillatory protein
• SCOPPH domain-containing family E member 1
• Suprachiasmatic nucleus circadian oscillatory protein

Background

PHLPP (PH domain leucine-rich repeat-containing protein phosphatase) is responsible for the dephosphorylation and subsequent inactivation of Akt. Akt is a signaling protein critical to the balance of cell survival and apoptosis. Dephosphorylation of Akt by PHLPP has been demonstrated to trigger apoptosis and suppress tumor cell growth. PHLPP functions similarly to its relative PHLPPL, also known as PHLPPL2. Recent studies show that PHLPP and PHLPPL selectively terminate Akt-signaling by targeting specific Akt isoforms. Alternate names for PHLPP include pleckstrin homology domain-containing family E protein 1, suprachiasmatic nucleus circadian oscillatory protein, hSCOP, PHLPP1, KIAA0606, PLEKHE1, and SCOP.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PHLPP1
• Uniprot:
  • NP_919431.1(Human)