PHLPP Products

Description

PHLPP (PH domain leucine-rich repeat-containing protein phosphatase) is responsible for the dephosphorylation and subsequent inactivation of Akt. Akt is a signaling protein critical to the balance of cell survival and apoptosis. Dephosphorylation of Akt by PHLPP has been demonstrated to trigger apoptosis and suppress tumor cell growth. PHLPP functions similarly to its relative PHLPPL, also known as PHLPPL2. Recent studies show that PHLPP and PHLPPL selectively terminate Akt-signaling by targeting specific Akt isoforms. Alternate names for PHLPP include pleckstrin homology domain-containing family E protein 1, suprachiasmatic nucleus circadian oscillatory protein, hSCOP, PHLPP1, KIAA0606, PLEKHE1, and SCOP.

Bioinformatics

Uniprot	NM_194449 Human O60346 Human
Product By Gene ID	23239
Alternate Names	EC 3.1.3.16 hSCOP KIAA0606 MGC161555 PH domain and leucine rich repeat protein phosphatase 1 PH domain and leucine rich repeat protein phosphatase PH domain leucine-rich repeat-containing protein phosphatase 1 PHLPP pleckstrin homology domain containing, family E (with leucine rich repeats)member 1 Pleckstrin homology domain-containing family E member 1 PLEKHE1 SCN circadian oscillatory protein SCOPPH domain-containing family E member 1 Suprachiasmatic nucleus circadian oscillatory protein

Research Areas for PHLPP

Find related products by research area and learn more about each of the different research areas below.

Cancer
Protein Phosphatase
Tumor Suppressors