PHLPP Products

Antibodies
PHLPP Antibody
PHLPP Antibody
NB100-1810
Species: Hu, Guinea Pig, Primate, Rabbit, Bat, Squirrel
Applications: IP, WB (-)
Host: Rabbit Polyclonal
PHLPP Antibody
PHLPP Antibody
NB100-1811
Species: Hu, Mu, Primate, Rhesus Macaque
Applications: WB, IP
Host: Rabbit Polyclonal
PHLPP Antibody
PHLPP Antibody
NBP2-33887
Species: Hu, Mouse, Rat
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
PHLPP Overexpression Lysate ( ...
PHLPP Overexpression Lysate (Native)
NBL1-14370
Applications: WB
Proteins
PHLPP Recombinant Protein Ant ...
PHLPP Recombinant Protein Antigen
NBP2-33887PEP
Species: Hu
Applications: AC
RNAi
PHLPP RNAi
PHLPP RNAi
H00023239-R02
Species: Hu

Description

PHLPP (PH domain leucine-rich repeat-containing protein phosphatase) is responsible for the dephosphorylation and subsequent inactivation of Akt. Akt is a signaling protein critical to the balance of cell survival and apoptosis. Dephosphorylation of Akt by PHLPP has been demonstrated to trigger apoptosis and suppress tumor cell growth. PHLPP functions similarly to its relative PHLPPL, also known as PHLPPL2. Recent studies show that PHLPP and PHLPPL selectively terminate Akt-signaling by targeting specific Akt isoforms. Alternate names for PHLPP include pleckstrin homology domain-containing family E protein 1, suprachiasmatic nucleus circadian oscillatory protein, hSCOP, PHLPP1, KIAA0606, PLEKHE1, and SCOP.

Bioinformatics

Uniprot Human
Human
Product By Gene ID 23239
Alternate Names
  • PLEKHE1
  • SCN circadian oscillatory protein
  • PHLPP
  • PH domain leucine-rich repeat-containing protein phosphatase 1
  • Suprachiasmatic nucleus circadian oscillatory protein
  • MGC161555
  • Pleckstrin homology domain-containing family E member 1
  • PH domain and leucine rich repeat protein phosphatase
  • KIAA0606
  • EC 3.1.3.16
  • pleckstrin homology domain containing, family E (with leucine rich repeats)member 1
  • SCOPPH domain-containing family E member 1
  • hSCOP
  • PH domain and leucine rich repeat protein phosphatase 1

Research Areas for PHLPP

Find related products by research area and learn more about each of the different research areas below.

Cancer
Protein Phosphatase
Tumor Suppressors

PTMs for PHLPP

Learn more about PTMs related to PHLPP.

Phosphorylation
Dephosphorylation
Ubiquitination

Bioinformatics Tool for PHLPP

Discover related pathways, diseases and genes to PHLPP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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