PHLPP Products

Description

Located on chromosome 18 and called PH domain Leucine-rich repeat Protein Phosphatase (PHLPP, pronounced "flip"), the tumor suppressor is described in the April 1, 2005 issue of the journal Molecular Cell. The scientists demonstrated that PHLPP deletes a phosphate molecule, causing termination of cell-growth signaling by a protein called Akt that controls the balance between cell growth leading to cancer and cell death that prevents tumor formation. PHLPP levels are markedly reduced in several colon cancer and gliobastoma human cell lines that had elevated Akt phosphorylation.

Bioinformatics

Product By Gene ID

23239

Alternate Names

EC 3.1.3.16 hSCOP KIAA0606 MGC161555 PH domain and leucine rich repeat protein phosphatase 1 PH domain and leucine rich repeat protein phosphatase PH domain leucine-rich repeat-containing protein phosphatase 1 PHLPP pleckstrin homology domain containing, family E (with leucine rich repeats)member 1 Pleckstrin homology domain-containing family E member 1 PLEKHE1 SCN circadian oscillatory protein SCOPPH domain-containing family E member 1 Suprachiasmatic nucleus circadian oscillatory protein

Research Areas for PHLPP

Find related products by research area and learn more about each of the different research areas below.

Cancer
Protein Phosphatase
Tumor Suppressors