PAR2 Antibody - BSA Free

Immunohistochemistry-Paraffin: PAR2 Antibody [NLS255] - Anti-F2RL1 / PAR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: PAR2 Antibody [NLS255] - Analysis of anti-F2RL1 / PAR2 antibody with human adrenal.

Immunohistochemistry-Paraffin: PAR2 Antibody [NLS255] - Human, Vascular smooth muscle: Formalin-Fixed Paraffin-Embedded (FFPE)

Immunohistochemistry-Paraffin: PAR2 Antibody [NLS255] - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

Immunohistochemistry-Paraffin: PAR2 Antibody [NLS255] - Anti-F2RL1 / PAR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Product Discontinued

PAR2 Antibody - BSA Free Summary

• Immunogen: Synthetic 18 amino acid peptide from C-terminus of human PAR2.
• Epitope: C-Terminus
• Localization: Integral membrane protein.
• Specificity: Human F2RL1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Hamster (94%), Bovine (94%), Rabbit (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: F2RL1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 - 10 ug/ml
• Application Notes: Use in Immunohistochemistry reported in scientific literature (PMID: 19889021).

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (89%), Porcine (89%), Opossum (89%), Mouse (83%), Canine (83%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PAR2 Antibody - BSA Free

• CFIIRL1
• coagulation factor II (thrombin) receptor-like 1
• Coagulation factor II receptor-like 1
• F2RL1
• GPCR11
• GPR11protease-activated receptor 2
• G-protein coupled receptor 11
• PAR2
• PAR-2
• PAR2G protein-coupled receptor-11
• proteinase-activated receptor 2
• proteinase-activated receptor-2
• Thrombin receptor-like 1

Background

The Proteinase-activated receptor 2 (PAR2) is a member of the proteinase-activated receptor subfamily. It is activated through proteolytic exposure of an occult tethered ligand by trypsin and trypsin-like proteases. This is in contrast to other members of the subfamily which are activated by the protease thrombin. PAR2 has been implicated in acute inflammatory response, asthma, and pain transmission. PAR2 expression has been documented in the periphery. ESTs have been isolated from adrenal, brain, breast, heart/melanocyte/uterus, kidney, lung, and vessel libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PAR2 Antibody (NLS255)(1)

Publication using NLS255

• Carvalho RF, Nilsson G, Harvima IT. Increased mast cell expression of PAR-2 in skin inflammatory diseases and release of IL-8 upon PAR-2 activation. Exp Dermatol 2010-02-01 [PMID: 19889021] (IF/IHC, Human)

Bioinformatics

• Gene Symbol: F2RL1
• Entrez:
  • 2150(Human)