Pannexin-3 Antibody (788905) [Alexa Fluor® 488]

• Applications: WB
• Clone: 788905
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

Pannexin-3 Antibody (788905) [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human Pannexin-3
  Tyr289-Thr384
  Accession # Q96QZ0
• Specificity: Detects human Pannexin-3 in ELISA.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Pannexin-3 (PANX3) is an approximately 45 kDa member of the Pannexin family of four-transmembrane channel proteins with a conserved pattern of cysteines. It is expressed in skin, cochlea, and developing hard tissues including cartilage and bone. In osteoblasts, it forms Ca2+ channels in the endoplasmic reticulum and promotes osteogenic differentiation. It also forms gap junction channels that pass Ca2+ between cells, and ATP-releasing hemichannels in the plasma membrane. Within aa 289-384 (in the C-terminal cytoplasmic domain), human Pannexin-3 shares 95% and 99% aa sequence identity with mouse and rat Pannexin-3, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.