PACE4/PCSK6 Antibody

Immunohistochemistry-Paraffin: PACE4/PCSK6 Antibody [NB110-39050] - Staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

Product Discontinued

PACE4/PCSK6 Antibody Summary

• Immunogen: Synthetic 17 amino acid peptide from internal region of human PACE4.
• Epitope: internal domain of human
• Specificity: Human PACE4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Monkey (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PCSK6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100 - 1:2000
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 20 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (94%), Marmoset (88%), Mouse (88%), Rat (88%), Bovine (88%), Canine (88%), Equine (88%), Porcine (88%), Opossum (88%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PACE4/PCSK6 Antibody

• EC 3.4.21
• EC 3.4.21.61
• EC 3.4.21.75
• PACE4
• PACE4/PCSK6
• PACE4EC 3.4.21.-
• Paired basic amino acid cleaving enzyme 4
• paired basic amino acid cleaving system 4
• PCSK6
• Proprotein Convertase 6
• proprotein convertase subtilisin/kexin type 6
• SPC4
• SPC4subtilisin-like protease
• Subtilisin/kexin-like protease PACE4
• Subtilisin-like proprotein convertase 4

Background

PACE4 is a Serine S8 type protease that cleaves precursor proteins at paired basic amino acid processing sites. Several PACE4 substrates have been identified, including transforming growth factor beta-related proteins, proalbumin and von Willebrand factor. At least eight alternatively spliced transcript variants encoding different isoforms have been reported. In mouse, PACE4 has been shown to increase tumor cell invasiveness, and thus enhance tumor progression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PCSK6
• Entrez:
  • 5046(Human)