PACE4/PCSK6 Antibody

Western Blot: PACE4 Antibody [H00005046-A01] - Analysis of PCSK6 expression in PC-12.

Western Blot: PACE4 Antibody [H00005046-A01] - Analysis of PCSK6 expression in Hela S3 NE (Cat # L013V3 ).

Western Blot: PACE4 Antibody [H00005046-A01] - Analysis of PCSK6 expression in NIH/3T3.

Western Blot: PACE4 Antibody [H00005046-A01] - Analysis of PCSK6 expression in Raw 264.7.

Product Discontinued

PACE4/PCSK6 Antibody Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: PCSK6 (NP_002561, 860 a.a. - 969 a.a.) partial recombinant protein with GST tag. REECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG
• Specificity: PCSK6 - proprotein convertase subtilisin/kexin type 6
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: PCSK6
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Protein Array
  • Western Blot
• Application Notes: Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for ELISA.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 50 % glycerol
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for PACE4/PCSK6 Antibody

• EC 3.4.21
• EC 3.4.21.61
• EC 3.4.21.75
• PACE4
• PACE4/PCSK6
• PACE4EC 3.4.21.-
• Paired basic amino acid cleaving enzyme 4
• paired basic amino acid cleaving system 4
• PCSK6
• Proprotein Convertase 6
• proprotein convertase subtilisin/kexin type 6
• SPC4
• SPC4subtilisin-like protease
• Subtilisin/kexin-like protease PACE4
• Subtilisin-like proprotein convertase 4

Background

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PACE4/PCSK6 Antibody (H00005046-A01)(2)

Publications using H00005046-A01

• Klee, George G, Vasmatzis, George, Kosari et al. EXTRACELLULAR AND MEMBRANE-ASSOCIATED PROSTATE CANCER MARKERS FreshPatents 2010-02-04 (ELISA, Human)
• Yang SF, Li SY, Lin FY et al. Chronic Kidney Disease Is Associated With Increased Cardiac Corin Expression But Decreased Proatrial Natriuretic Peptide Conversion Activity Journal of the American Heart Association 2022-07-19 [PMID: 35861835]

Bioinformatics

• Gene Symbol: PCSK6
• Entrez:
  • 5046(Human)
• OMIM:
  • 167405(Human)
• Uniprot:
  • NP_002561()