PACE4 Antibody

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Immunohistochemistry-Paraffin: PACE4 Antibody [NB110-39050] - Staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ...read more

Product Details

Summary
Reactivity Hu, Rb, MkSpecies Glossary
Applications ELISA, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

PACE4 Antibody Summary

Immunogen
Synthetic 17 amino acid peptide from internal region of human PACE4.
Epitope
internal domain of human
Specificity
Human PACE4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Monkey (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PCSK6
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100 - 1:2000
  • Immunohistochemistry-Paraffin 20 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gibbon (94%), Marmoset (88%), Mouse (88%), Rat (88%), Bovine (88%), Canine (88%), Elephant (88%), Panda (88%), Equine (88%), Porcine (88%), Opossum (88%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PACE4 Antibody

  • EC 3.4.21
  • EC 3.4.21.61
  • EC 3.4.21.75
  • PACE4EC 3.4.21.-
  • Paired basic amino acid cleaving enzyme 4
  • paired basic amino acid cleaving system 4
  • proprotein convertase subtilisin/kexin type 6
  • SPC4subtilisin-like protease
  • Subtilisin/kexin-like protease PACE4
  • Subtilisin-like proprotein convertase 4

Background

PACE4 is a Serine S8 type protease that cleaves precursor proteins at paired basic amino acid processing sites. Several PACE4 substrates have been identified, including transforming growth factor beta-related proteins, proalbumin and von Willebrand factor. At least eight alternatively spliced transcript variants encoding different isoforms have been reported. In mouse, PACE4 has been shown to increase tumor cell invasiveness, and thus enhance tumor progression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PCSK6
Entrez