p57 Kip2 Antibody (KIP2/7187) [Alexa Fluor™ Plus 680]

• Reactivity: Hu, Mu
• Applications: IHC
• Clone: KIP2/7187
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 680

p57 Kip2 Antibody (KIP2/7187) [Alexa Fluor™ Plus 680] Summary

• Immunogen: Recombinant full-length human p57 Kip2 protein
• Localization: Nucleus.
• Specificity: Recognizes a protein of 57kDa, identified as p57 Kip2 It shows no cross-reaction with p27Kip1
• Isotype: IgG Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: CDKN1C
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for p57 Kip2 Antibody (KIP2/7187) [Alexa Fluor™ Plus 680]

• Beckwith-Wiedemann syndrome
• BWS
• cyclin-dependent kinase inhibitor 1C (p57, Kip2)
• cyclin-dependent kinase inhibitor 1C
• Cyclin-dependent kinase inhibitor p57
• KIP2BWCR
• p57
• p57Kip2
• WBS

Background

p57kip2 is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CDKN1C