P2X7/P2RX7 Antibody (545230) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 545230
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

P2X7/P2RX7 Antibody (545230) [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human P2X7/P2RX7
  Asp356-Tyr595
  Accession # Q99572
• Specificity: Detects human P2X7/P2RX7 in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for P2X7/P2RX7 Antibody (545230) [Alexa Fluor® 488]

• ATP receptor
• MGC20089
• P2RX7
• P2X purinoceptor 7
• P2X7
• P2X7P2X7 receptor
• P2X7R
• P2Z receptor
• purinergic receptor P2X, ligand-gated ion channel, 7
• purinergic receptor P2X7 variant A
• Purinergic receptor

Background

Human P2X purinoceptor 7 (aka P2X7) is a 595 aminoacids (aa) protein encoded by the P2RX7 gene. P2X7 receptors belong to the family of ATP-gated ion channels, and their activity can be found in cells of hemopoietic lineage including macrophages, microglia, and certain lymphocytes. They mediate the influx of Ca2+ and Na+ and the release of pro-inflammatory cytokines. At least 8 different human P2X7 isoforms formed by alternative splicing have been reported, ranging from 128 aa to 595 aa. The P2X7 subunits can form homomeric receptors only with a typical P2X receptor structure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.