P2X1/P2RX1 Antibody (551820) [Janelia Fluor® 549]

• Reactivity: Hu
• Applications: Flow, CyTOF-ready
• Clone: 551820
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 549

P2X1/P2RX1 Antibody (551820) [Janelia Fluor® 549] Summary

• Immunogen: Human embryonic kidney cell, HEK293-derived transfected with human P2X1/P2RX1
  Accession # P51575
• Specificity: Detects human P2X1/P2RX1 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for P2X1/P2RX1 Antibody (551820) [Janelia Fluor® 549]

• ATP receptor
• P2RX1
• P2X purinoceptor 1
• P2X receptor, subunit 1
• P2X1
• P2X1P2X1 receptor
• P2XMR
• purinergic receptor P2X, ligand-gated ion channel, 1
• Purinergic receptor

Background

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.