p120-catenin Antibody (DBM15.55)

• Reactivity: Hu
• Applications: IHC
• Clone: DBM15.55
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

p120-catenin Antibody (DBM15.55) Summary

• Description: Novus Biologicals Mouse p120-catenin Antibody (DBM15.55) (NBP3-45114) is a monoclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Recombinant human p120 Catenin protein fragment
• Specificity: p120 Catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, p120 catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, p120 catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of p120 catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immune-staining of p120 catenin and E-cadherin helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in sito (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic p120 catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: CTNND1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: PBS (pH 7.4), Tween-20, 0.2% BSA
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Alternate Names for p120-catenin Antibody (DBM15.55)

• Cadherin-associated Src substrate
• CAS
• catenin (cadherin-associated protein), delta 1
• catenin delta-1
• CTNND
• KIAA0384P120CAS
• p120 catenin
• p120
• p120(CAS)
• p120(CTN)
• p120cas
• p120ctn

Background

The alpha, beta, delta, and gamma -catenins are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. alpha-catenin, a 102 kDa protein, interacts with E-cadherin associated protein, and also associates with other members of the cadherin family, such as N-cadherin and P-cadherin. The 92 kDa beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. beta-catenin also complexes with the tumor suppressor protein APC. delta-catenin interacts with Presenilin 1 and is expressed in the brain. The gene encoding delta-catenin maps to human chromosome 5p15.2. A hemizygous loss of the gene encoding delta-catenin leads to the mental retardation associated with Cri-du-Chat syndrome. gamma-catenin, also known as plakoglobin, is an 80-88 kDa protein that binds alpha-catenin and N-cadherin. In addition, the transmembrane phosphatase PTPm associates with catenin/cadherin complexes and may regulate complex signaling.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CTNND1