p107 Antibody (KAB6)

Product Discontinued

p107 Antibody (KAB6) Summary

• Immunogen: Recombinant GST protein to the N terminus of p107
• Specificity: KAB6 recognizes both the phosphorylated and unphosphorylated forms of p107 at a MW of 107 kDa.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: RBL1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:1000
• Application Notes: .

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.08% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for p107 Antibody (KAB6)

• cellular protein 107,107 kDa retinoblastoma-associated protein
• cp107
• p107MGC40006
• PRB1
• retinoblastoma-like 1 (p107)
• retinoblastoma-like protein 1

Background

The immunogen used was a recombinant protein to the N terminus of p107. p107 is related both in structure and function to the retinoblastoma tumor suppressor protein and p130 (collectively known as pocket proteins) and are known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S-phase of the cell cycle. Binding of p107 converts E2F transcription factors from transcriptional activators to transcriptional repressors. KAB6 recognizes both the phosphorylated and unphosphorylated forms of p107 at a MW of 107 kDa.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RBL1