OCRL Antibody (S166A-26) [DyLight 488]

Product Discontinued

OCRL Antibody (S166A-26) [DyLight 488] Summary

• Immunogen: Fusion protein amino acids 1-901 (full-length) of human INPP5F. Rat: 93% identity (845/904 amino acids identical). Mouse: 91% identity (824/901 amino acids identical) ~50% identity with INPP5b.
• Localization: Cytoplasmic Vesicle , Endosome , Endosome Membrane , Membrane , Golgi Apparatus
• Specificity: Approx 50% identity with INPP5b.Detects approx 100kDa. Cross-reacts with INPP5b.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: OCRL
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Immunogen displays sequence identity for non-tested species: Mouse and Rat.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for OCRL Antibody (S166A-26) [DyLight 488]

• EC 3.1.3.36
• INPP5F
• LOCR
• Lowe oculocerebrorenal syndrome protein
• NPHL2
• OCRL1inositol polyphosphate 5-phosphatase OCRL-1
• oculocerebrorenal syndrome of Lowe
• phosphatidylinositol polyphosphate 5-phosphatase

Background

OCRL encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: OCRL