Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody (585713) [Alexa Fluor® 532]

• Reactivity: Hu
• Applications: Flow, IHC, CyTOF-ready
• Clone: 585713
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody (585713) [Alexa Fluor® 532] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human CHRM2
  Accession # P08172
• Specificity: Detects human CHRM2 in immunohistochemistry.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: CHRM2
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody (585713) [Alexa Fluor® 532]

• 7TM receptor
• cholinergic receptor, muscarinic 2
• CHRM2
• FLJ43243
• HM2
• mAChR M2
• MGC120006
• MGC120007
• muscarinic acetylcholine receptor M2
• muscarinic M2 receptor

Background

Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction. The channel-linked AChR that mediates rapid, excitatory actions of acetylcholine is called nicotinic AChR (nAChR) because it can be activated by nicotine. The non-channel linked AChR that medicates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine. The mAChRs are present in neurons of the central and peripheral nervous systems, cardiac and smooth muscle and various exocrine glands. There are 5 subtypes (m1-m5) of the receptor that have a tissue specific pattern of expression. The m2 receptor is localized primarily in cardiac tissue and is also expressed at low levels in the hippocampus, cortex, striatum, thalamus, basal forebrain, brainstem, lung, vas deferens and uterus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CHRM2