MSY2 Antibody

Product Discontinued

MSY2 Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 287-325 of Human MSY2.
• Specificity: MSY2 (G311) detects endogenous levels of MSY2 (G311) protein.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: YBX2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:50-1:200
  • Western Blot 1:500-1:1000
• Application Notes: Western blot (WB) analysis of MSY2 (G311) pAb in extracts from COLO205 cells.
• Theoretical MW: 38 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

This antibody is reactive against Human, Mouse.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for MSY2 Antibody

• Contrin
• CSDA3MGC45104
• DBPC
• DNA-binding protein C
• Germ cell-specific Y-box-binding protein
• MSY2 homolog
• MSY2germ cell specific Y-box binding protein
• Y box binding protein 2
• Y-box-binding protein 2

Background

Contrin (MSY2 in mouse) and YB-2 (MSY3/4 in mouse) belong to the Y-box family of multifunctional proteins that regulate both transcription and translation. Y-box proteins interact with a wide variety of nucleic acid structures to act as transcription factors and mRNA masking proteins. The modular structure of Y-box proteins includes a highly conserved N-terminal cold-shock domain (CSD, equivalent to the bacterial cold-shock proteins) and four basic C-terminal domains containing arginine clusters and aromatic residues. MSY2 (Contrin) is a expressed in testis and ovary, where it may repress translation of parental mRNA. The gene encoding human Contrin maps to chromosome 17p11.2-13.1. MSY3/4 (YB-2) is also known as DNA binding protein A and is highly expressed in testis, heart and muscle. Contrin and YB-2 bind to the consensus sequence 5'-UCCAUCA-3' contained in the Y-box element .

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: YBX2
• Entrez:
  • 51087(Human)