Mouse R-Spondin 3 DuoSet ELISA, 5 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse R-Spondin 3 DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Rspo3

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse R-Spondin 3 DuoSet ELISA, 5 Plate

• Cristin 1
• CRISTIN1
• FLJ14440
• hPWTSR
• hRspo3
• Protein with TSP type-1 repeat
• PWTSR
• Roof plate-specific spondin-3
• RSPO3
• R-spondin 3 homolog (Xenopus laevis)
• RSpondin 3
• R-Spondin 3
• R-spondin-3
• Thrombospondin type-1 domain-containing protein 2
• thrombospondin, type I, domain containing 2
• THSD2

Background

R-Spondin 3 (RSPO3; Cristin 1) is a secreted Wnt regulating protein that is critical for development of the placental labyrinthine layer. It is expressed in the roof plate, tail, somites, otic vesicles, cephalic mesoderm, truncus arteriosus, atrioventricular canal of the developing heart, and strongly but transiently in developing limbs. R-Spondins regulate Wnt/ beta -catenin by competing with the Wnt antagonist DKK-1 for binding to the Wnt co-receptors LRP-6 and Kremen, reducing their DKK-1-mediated internalization. Reports differ on whether R-Spondins bind LRP-6 directly.

Publications for R-Spondin 3 (DY4120-05)(1)

Publication using DY4120-05

• R Ogasawara, D Hashimoto, S Kimura, E Hayase, T Ara, S Takahashi, H Ohigashi, K Yoshioka, T Tateno, E Yokoyama, K Ebata, T Kondo, J Sugita, M Onozawa, T Iwanaga, T Teshima Intestinal Lymphatic Endothelial Cells Produce R-Spondin3 Sci Rep, 2018-07-16;8(1):10719. 2018-07-16 [PMID: 30013036] (Mouse)

Bioinformatics

• Gene Symbol: Rspo3