MARCKS [p Ser152, p Ser156] Antibody

Product Discontinued

MARCKS [p Ser152, p Ser156] Antibody Summary

• Immunogen: Synthetic peptide corresponding to amino acids surrounding Ser152/156 of rat MARCKS.
• Modification: p Ser152, p Ser156
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MARCKS
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Western blotting (1:200-1000). However, the optimal conditions should be determined individually. Other applications have not been determined. The antibody detects 80 kDa MARCKS only when phosphorylated at Ser152/156.

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2), 1.0% BSA and 50% Glycerol
• Preservative: 0.02% Thimerosal
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for MARCKS [p Ser152, p Ser156] Antibody

• 80K-L protein
• 80K-L
• FLJ14368
• MACS
• MACSmyristoylated alanine-rich C-kinase substrate
• MARCKS
• MRACKS
• myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L)
• myristoylated alanine-rich protein kinase C substrate
• phosphomyristin
• PKCSLFLJ90045
• PRKCSL
• Protein kinase C substrate, 80 kDa protein, light chain

Background

Myristolyated alanine rich C-kinase substrate, hence MARCKS, was originally discovered as a major substrate for protein kinase C in the brain and other tissues, and was originally isolated from human epithelial cells. MARCKS is a major protein of brain, and is concentrated in synapses of neurons. It appears to function in synaptic vesicle cycling and has been shown to bind both actin and calmodulin in vitro. MARCKS belongs to a family of proteins with similar actin and calmodulin binding properties. Deletion of the MARCKS gene in mice results in embryonic brain defects and death.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MARCKS
• Entrez:
  • 4082(Human)
• Uniprot:
  • P30009(Rat)