Kv7.4 Antibody (2H6) - Azide and BSA Free

Western Blot: Kv7.4 Antibody (2H6) [H00009132-M01] - KCNQ4 monoclonal antibody (M01), clone 2H6 Analysis of KCNQ4 expression in IMR-32.

Western Blot: Kv7.4 Antibody (2H6) [H00009132-M01] - KCNQ4 monoclonal antibody (M01), clone 2H6. Analysis of KCNQ4 expression in NIH/3T3.

Sandwich ELISA: Kv7.4 Antibody (2H6) [H00009132-M01] - Detection limit for recombinant GST tagged KCNQ4 is approximately 1ng/ml as a capture antibody.

• Reactivity: Hu, Mu
• Applications: WB, ELISA
• Clone: 2H6
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

Kv7.4 Antibody (2H6) - Azide and BSA Free Summary

• Immunogen: KCNQ4 (NP_004691, 596 a.a. ~ 695 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. AREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
• Specificity: KCNQ4 (2H6)
• Isotype: IgG3 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: KCNQ4
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Sandwich ELISA
  • Western Blot 1:500
• Application Notes: Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Kv7.4 Antibody (2H6) - Azide and BSA Free

• DFNA2
• DFNA2A
• KCNQ4
• KQT-like 4
• Kv7.4
• potassium channel KQT-like 4
• Potassium channel subunit alpha KvLQT4
• potassium voltage-gated channel subfamily KQT member 4
• potassium voltage-gated channel, KQT-like subfamily, member 4
• Voltage-gated potassium channel subunit Kv7.4

Background

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNQ4
• Entrez:
  • 9132(Human)
• OMIM:
  • 600101(Human)
• Uniprot:
  • NP_004691(Human)