ING4 Antibody Blocking Peptide

• Reactivity: Hu
• Applications: AC

ING4 Antibody Blocking Peptide Summary

• Description: A Human ING4 antibody blocking peptide
  
  Source: Synthetic (Accession #: Q9UNL4)
  
  Store vial at -20C prior to opening. Aliquot contents and freeze at -20C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4C as an undiluted liquid. Dilute only prior to immediate use.
• Source: Synthetic
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: ING4
• Purity: >95%

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This product should be used at 1.0 ug per 1.0 ul of antiserum in per assay.

Packaging, Storage & Formulations

• Storage: Store at -20C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.
• Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
• Preservative: 0.01% Sodium Azide
• Purity: >95%

Alternate Names for ING4 Antibody Blocking Peptide

• candidate tumor suppressor p33 ING1 homolog
• inhibitor of growth family, member 4
• inhibitor of growth protein 4
• MGC12557
• my036
• p29ING4brain my036 protein

Background

p29 ING4 is a tumor suppressor protein similar to ING1 that may inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. p29 ING4 has been shown to suppress brain tumor angio-genesis through transcriptional repression of RelA/ NFKB3 target genes when complexed with RelA. p29 ING4 may also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. p29 ING4 shows a nuclear localization and interacts with EP300, TP53, RelA, inhibits cell growth, and induces apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. Multiple alternatively spliced transcript variants have been observed. The accession number listed below is for variant (1) that encodes the longest isoform.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: ING4
• Uniprot:
  • Q9UNL4(Human)