ICAM-5 Antibody (191321)

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB
Clone
191321
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

ICAM-5 Antibody (191321) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse ICAM‑5
Leu31-Arg828 (Pro47Arg)
Accession # Q60625
Specificity
Detects mouse ICAM-5 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross-react with recombinant mouse (rm) DCC, rmICAM-1, rhICAM-1, rmICAM-2, rhICAM-3, rmMadCAM, rhCD31, or rmVCAM‑1.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
ICAM5
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ICAM-5 Antibody (191321)

  • ICAM5
  • ICAM-5
  • intercellular adhesion molecule 5
  • intercellular adhesion molecule 5, telencephalin
  • Telencephalin
  • TLCNTelencephalin
  • TLNtelencephalin

Background

Intercellular adhesion molecule-5 (ICAM-5), also known as telencephalin, is an integral membrane glycoprotein expressed in neurons of mammalian telencephalons. ICAM-5 is a member of the immunoglobulin superfamily and shares 38-55% amino acid homology with other ICAMs. Structurally, ICAM-5 contains nine Ig domains that included 15 N-glycosylation sites, a single transmembrane region, and C-terminal cytoplasmic tail (1). As with other members of the ICAM family, ICAM-5 has been shown to be involved in cellular adhesion. ICAM-5 binds to the leukocyte integrin LFA-1 (CD11a/CD18) via its first NH2-terminal Ig domain. The ability of ICAM-5 to bind LFA-1 suggests that ICAM-5 may play an important role in immune responses in the central nervous system (2). Additionally, ICAM-5 has been found to promote homophilic binding via binding of the first Ig domain to Ig domains 4-5. Homophilic adhesion activity of ICAM-5 is regulated by a monomer/tetramer transition. ICAM-5 expression temporally parallels the onset of dendritic elongation and synaptogenesis during the postnatal period suggesting that ICAM-5 may provide a brain segment-specific cue for synaptogenesis or dendrite-dendrite interaction (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ICAM5
Entrez
Uniprot