ICAM-5 Antibody (191321) [Janelia Fluor® 549]

• Reactivity: Mu
• Applications: WB
• Clone: 191321
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Janelia Fluor 549

ICAM-5 Antibody (191321) [Janelia Fluor® 549] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse ICAM‑5
  Leu31-Arg828 (Pro47Arg)
  Accession # Q60625
• Specificity: Detects mouse ICAM-5 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross-react with recombinant mouse (rm) DCC, rmICAM-1, rhICAM-1, rmICAM-2, rhICAM-3, rmMadCAM, rhCD31, or rmVCAM‑1.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: ICAM5
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for ICAM-5 Antibody (191321) [Janelia Fluor® 549]

• ICAM5
• ICAM-5
• intercellular adhesion molecule 5
• intercellular adhesion molecule 5, telencephalin
• Telencephalin
• TLCNTelencephalin
• TLNtelencephalin

Background

ICAM5 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ICAM5