Human IL-29/IFN-lambda 1 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-29/IFN-lambda 1 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IFNL1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-29/IFN-lambda 1 DuoSet ELISA, 15 Plate

• cytokine Zcyto21
• IFNL1
• IFN-lambda 1
• IFN-lambda-1
• IL29
• IL-29
• interferon lambda-1
• interferon, lambda 1
• interleukin 29 (interferon, lambda 1)
• interleukin-29
• ZCYTO21

Background

Human/mouse IL-28A (IFN-lambda 2), IL-28B (IFN-lambda 3), and human IL-29 (IFN-lambda 1) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid (aa) sequence identity) and type I IFN family (15 - 19% aa sequence identity). These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 R beta) and a novel IL-28 receptor alpha (IL-28 R alpha, also known as IFN-lambda R1). Mouse IL-28 shares 61%, 62%, and 52% aa identity with human IL-28A, IL-28B, and IL-29, respectively.

Publications for IL-29/IFN-lambda 1 (DY7246)(13)

Publications using DY7246

• A Rajamanick, NP Kumar, AN Pandiaraj, N Selvaraj, S Munisankar, RM Renji, V Venkatrama, M Murhekar, JWV Thangaraj, MS Kumar, CPG Kumar, T Bhatnagar, M Ponnaiah, R Sabarinath, V Saravanaku, S Babu Restoration of dendritic cell homeostasis and Type I/Type III interferon levels in convalescent COVID-19 individuals BMC immunology, 2022-10-26;23(1):51. 2022-10-26 [PMID: 36289478] (Human)
• Y Fukuda, T Homma, H Inoue, Y Goto, Y Sato, H Ikeda, C Onitsuka, H Sato, K Akimoto, T Ebato, H Suganuma, T Kawahara, H Mikuni, Y Uchida, S Suzuki, A Tanaka, H Sagara Serum IL-28A/IFN-lambda2 is linked to disease severity of COVID-19 Scientific Reports, 2022-03-31;12(1):5458. 2022-03-31 [PMID: 35361913] (Human)
• EL Johnson, D Swieboda, A Olivier, EAL Enninga, R Chakrabort Robust innate immune responses at the placenta during early gestation may limit in utero HIV transmission PloS Pathogens, 2021-08-25;17(8):e1009860. 2021-08-25 [PMID: 34432853] (Human)
• TM Yendo, MN Sato, ACCC Branco, AJ Pietrobon, FME Teixeira, YÁL Ramos, RW Alberca, CG Valêncio, VN Arruda, R Romiti, M Arnone, ALDS Hirayama, AJDS Duarte, V Aoki, RL Orfali Impact of Inflammatory Immune Dysfunction in Psoriasis Patients at Risk for COVID-19 Vaccines, 2021-05-10;9(5):. 2021-05-10 [PMID: 34068473] (Human)
• Fanny Onodi, Lucie Bonnet-Madin, Laurent Meertens, Léa Karpf, Justine Poirot, Shen-Ying Zhang et al. SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4 Journal of Experimental Medicine 2021-04-05 [PMID: 33533916] (Human)
• F Onodi, L Bonnet-Mad, L Meertens, L Karpf, J Poirot, SY Zhang, C Picard, A Puel, E Jouanguy, Q Zhang, J Le Goff, JM Molina, C Delaugerre, JL Casanova, A Amara, V Soumelis SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4 bioRxiv : the preprint server for biology, 2021-01-08;0(0):. 2021-01-08 [PMID: 33442685] (Human)
• L Wisgrill, I Wessely, A Netzl, L Pummer, K Sadeghi, A Spittler, A Berger, E Förster-Wa Diminished secretion and function of IL-29 is associated with impaired IFN-? response of neonatal plasmacytoid dendritic cells J. Leukoc. Biol., 2019-06-18;0(0):. 2019-06-18 [PMID: 31211458] (Human)
• S Albertini, I Lo Cigno, F Calati, M De Andrea, C Borgogna, V Dell'Oste, S Landolfo, M Gariglio HPV18 Persistence Impairs Basal and DNA Ligand-Mediated IFN-? and IFN-?Production through Transcriptional Repression of Multiple Downstream Effectors of Pattern Recognition Receptor Signaling J. Immunol., 2018-01-31;0(0):. 2018-01-31 [PMID: 29386255] (Human)
• J Corry, N Arora, CA Good, Y Sadovsky, CB Coyne Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal-fetal interface Proc. Natl. Acad. Sci. U.S.A., 2017-08-07;0(0):. 2017-08-07 [PMID: 28784796] (Human)
• MC Mladinich, J Schwedes, ER Mackow Zika Virus Persistently Infects and Is Basolaterally Released from Primary Human Brain Microvascular Endothelial Cells MBio, 2017-07-11;8(4):. 2017-07-11 [PMID: 28698279] (Human)
• Travanty E, Zhou B, Zhang H, Di Y, Alcorn J, Wentworth D, Mason R, Wang J Differential Susceptibilities of Human Lung Primary Cells to H1N1 Influenza Viruses. J Virol, 2015-09-16;89(23):11935-44. 2015-09-16 [PMID: 26378172] (Human)
• Wu Q, Jiang D, Huang C, van Dyk L, Li L, Chu H Trehalose-mediated autophagy impairs the anti-viral function of human primary airway epithelial cells. PLoS ONE, 2015-04-16;10(4):e0124524. 2015-04-16 [PMID: 25879848] (Human)
• Osterlund P, Strengell M, Sarin L, Poranen M, Fagerlund R, Melen K, Julkunen I Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry. J Virol, 2012;86(20):11183-93. 2012 [PMID: 22855501] (Human)

Bioinformatics

• Gene Symbol: IFNL1