HOXC6 Antibody

Product Discontinued

HOXC6 Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 191-240 of Human Hox-C6.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: HOXC6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000
• Application Notes: Western blot (WB) analysis of Hox-C6 (G220) pAb in extracts from HUVEC cells.
  Immunohistochemistry (IHC) analyzes of Hox-C6 (G220) pAb in paraffin-embedded human heart tissue.
• Theoretical MW: 26 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control:

  HOXC6 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for HOXC6 Antibody

• CP25
• HHO.C8
• homeo box 3C
• homeo box C6
• homeo box C8 protein
• homeobox C6
• Homeobox protein CP25
• Homeobox protein HHO.C8
• Homeobox protein Hox-3C
• homeobox protein Hox-C6
• HOX3CHOX3

Background

The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. The mammalian Hox gene complex consists of 39 genes that are located on four linkage groups, which are dispersed over four chromosomes. Hox genes that occupy the same relative position along the 5' to 3' coordinate (trans-paralogous genes) are more similar in sequence and expression pattern than adjacent Hox genes on the same chromosome. HoxC6 sequence-specific transcription factor is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. HoxC6 may be a novel potential therapeutic target for prostate cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for HOXC6 Antibody (NB100-92309)(1)

Publication using NB100-92309

• Ji M, Feng Q, He G et al. Silencing homeobox C6 inhibits colorectal cancer cell proliferation. Oncotarget. 2016-05-17 [PMID: 27081081] (Human)

Bioinformatics

• Gene Symbol: HOXC6
• Entrez:
  • 3223(Human)
  • 15425(Mouse)
• Uniprot:
  • P09630(Human)