Histone H2a [ac Lys9] Antibody (23GB6080)

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, Flow, ICC/IF
Clone
23GB6080
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Histone H2a [ac Lys9] Antibody (23GB6080) Summary

Immunogen
A synthesized peptide derived from human Histone H2a (acetyl K9) (Uniprot: P04908)
Modification
ac Lys9
Specificity
This antibody detects endogenous levels of H2AC4 only when Acetylated at K9
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
H2AC20
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4), 50% glycerol
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for Histone H2a [ac Lys9] Antibody (23GB6080)

  • H2A histone family, member Q
  • H2A/q
  • H2A1B
  • H2AFQH2A
  • H2A-GL101
  • HIST1H2AB
  • histone 2, H2ac
  • histone cluster 2, H2ac
  • histone H2A type 2-C
  • Histone H2A
  • Histone H2A/q
  • Histone H2A-GL101
  • histone IIa
  • MGC74460

Background

Changes in chromatin structure play a large role in the regulation of transcription in eukaryotes (1). The nucleosome is the primary building block of chromatin, and is made up of four core histone proteins (H2A, H2B, H3 and H4) (2). It has been shown that DNA damage induces monoubiquitylation of histone H2A in the vicinity of DNA lesions. Ultraviolet -induced monoubiquitylation of H2A is dependent on functional nucleotide excision repair. It occurs after incision of the damaged strand and forms part of the cellular response to UV damage and suggests a role of this modification in DNA repair-induced chromatin remodeling (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol H2AC20