GPR37 Antibody (1036313) [mFluor Violet 500 SE]

• Reactivity: Hu
• Applications: WB
• Clone: 1036313
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: mFluor Violet 500 SE

GPR37 Antibody (1036313) [mFluor Violet 500 SE] Summary

• Immunogen: Chinese Hamster Ovary cell line CHO-derived human GPR37
  Leu28-Met265
  Accession # O15354
• Specificity: Detects human GPR37 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for GPR37 Antibody (1036313) [mFluor Violet 500 SE]

• EDNRBL
• Endothelin B receptor-like protein 1
• ETBR-LP-1
• G protein-coupled receptor 37 (endothelin receptor type B-like)
• GPR37
• hET(B)R-LP
• PAELR
• PAELRETBR-LP-1
• Parkin-associated endothelin receptor-like receptor
• probable G-protein coupled receptor 37

Background

GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death. GPR37 expression has been reported in brain, liver, and placenta. ESTs have been isolated from brain, embryo, eye, fetal lung/testis/Bcell, gallbladder, heart, liver, liver/spleen, melanocyte/uterus/fetal heart, nerve, placenta, testis, tonsil, and vessel libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.