FREM2 Antibody

Product Discontinued

FREM2 Antibody Summary

• Immunogen: Antibody was raised against a 19 amino acid synthetic peptide near the center of human FREM2. The immunogen is located within amino acids 1920 - 1970 of FREM2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: FREM2
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 1:10-1:2000
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for FREM2 Antibody

• ECM3 Homolog
• FRAS1 Related Extracellular Matrix Protein 2

Background

FREM2 is a member of the FRAS1-related extracellular matrix protein family and like FREM1, mutations in the FREM2 gene are associated with Fraser syndrome. FREM2 localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes and is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The FREM2 gene is one of several genes whose transcription is affecteded by TFAP2C, a transcription factor involved in mammary development, differentiation, and oncogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FRAS1 (Fraser syndrome 1) Antibody (NBP1-77181)(1)

Publication using NBP1-77181

• Vidak Marko, Jovcevska Ivana, Samec Neja et al. Meta-Analysis and Experimental Validation Identified FREM2 and SPRY1 as New Glioblastoma Marker Candidates. International Journal of Molecular Sciences 2018-05-04 [PMID: 29734672] (WB, Human)

Bioinformatics

• Gene Symbol: FREM2
• Uniprot:
  • NP_997244(Human)