FKBP38 Antibody

Images

 
Western Blot: FKBP38 Antibody [NB110-85535] - Analysis of exogenous FKBP8 in 50 ug of HEK293T whole cell lysate (lane 1). The results of peptide competition are shown in lane 2 where no specific staining is noted after ...read more
Western Blot: FKBP38 Antibody [NB110-85535] - protein A purified anti-FKBP8 antibody shows detection of exogenous FKBP8 in 50 ug of HEK293T whole cell lysate (lane 1). The results of peptide competition are shown in ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

FKBP38 Antibody Summary

Immunogen
This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human FKBP8 protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
FKBP8
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:2000
  • ELISA 1:25000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
This protein A purified antibody has been tested for use in ELISA and western blotting. Expect a band approximately 64 kDa in size corresponding - FKBP8 by western blotting in the appropriate cell lysate or extract.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse (93%), Rat (93%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative
0.01% Sodium Azide
Purity
Protein A purified

Alternate Names for FKBP38 Antibody

  • 38 kDa FK506-binding protein
  • EC 5.2.1.8,38 kDa FKBP
  • FK506 binding protein 8, 38kDa
  • FK506-binding protein 8 (38kD)
  • FK506-binding protein 8
  • FKBP38
  • FKBP-38
  • FKBP38PPIase FKBP8
  • FKBP8
  • FKBP-8
  • FKBPr38
  • hFKBP38
  • peptidyl-prolyl cis-trans isomerase FKBP8
  • rotamase

Background

FKBP8 (also known as FK506-binding protein 38) is a member of the immunophilin family that has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP8 by RNAi or transfection of a mutant FKBP8 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP8 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol FKBP8
Entrez
Uniprot