Ext2 Antibody

Product Discontinued

Ext2 Antibody Summary

• Immunogen: Peptide with sequence C-PLKVVEHRADPVL corresponding to C-Terminus according to NP_997005.1.
• Epitope: C-PLKVVEHRADPVL
• Specificity: This antibody is expected to recognize isoform 1 and 2 (NP_000392.2; NP_997005.1).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: EXT2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:8000
• Application Notes: WB: Preliminary experiments in lysates of HEK293 gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for Ext2 Antibody

• EC 2.4.1.224
• EC 2.4.1.225
• exostoses (multiple) 2
• Exostosin 2
• exostosin-2
• EXT2
• Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan4-alpha-N-acetylglucosaminyltransferase
• Multiple Exostoses Protein 2
• N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase
• Putative tumor suppressor protein EXT2
• SOTV

Background

This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Ext2 Antibody (NBP1-52137)(1)

Publication using NBP1-52137

• Rong R, Hanson RL, Ortiz D et al. Association Analysis of Variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761 and CDKN2B with Type 2 Diabetes and Related Quantitative Traits in Pima Indians. Diabetes 2008-11-13 [PMID: 19008344]

Bioinformatics

• Gene Symbol: EXT2
• Entrez:
  • 2132(Human)
  • 14043(Mouse)
  • 311215(Rat)
• Uniprot:
  • NP_000392.2(Human)