EN-RAGE/S100A12 Antibody (001) [Alexa Fluor™ Plus 555]

• Reactivity: Hu
• Applications: ELISA
• Clone: 001
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 555

EN-RAGE/S100A12 Antibody (001) [Alexa Fluor™ Plus 555] Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: This antibody was obtained from a rabbit immunized with purified, recombinant Human EN-RAGE/S100A12 (Accession#: NP_005612.1; Met1-Glu92).
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: S100A12
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for EN-RAGE/S100A12 Antibody (001) [Alexa Fluor™ Plus 555]

• CAAF1
• CAAF1Neutrophil S100 protein
• CAAFI
• CAGC
• CAGCS100 calcium binding protein A12 (calgranulin C)
• CAGCS100
• Calcium-binding protein in amniotic fluid 1
• Calgranulin C
• calgranulin-C
• CGRPEN-RAGE
• ENRAGE
• EN-RAGE
• Extracellular newly identified RAGE-binding protein
• MRP6
• p6calgranulin C
• protein S100-A12
• S100 calcium binding protein A12
• S100 calcium-binding protein A12 (calgranulin C)
• S100 calcium-binding protein A12
• S100A12

Background

S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B--a key transcription factor for inflammatory events--is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: S100A12