EDAR Antibody (RM0077-8L53)

Product Discontinued

EDAR Antibody (RM0077-8L53) Summary

• Immunogen: Mouse recombinant EC-domain of EDAR
• Specificity: This was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with mouse recombinant Extracellular Domain of EDAR.
• Isotype: IgG2
• Clonality: Monoclonal
• Host: Rat
• Gene: EDAR
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:1000
• Application Notes: This antibody detects mouse EDRA in Western blotting and cross reacts with human EDAR.

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from 0.2 um filtered PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein G purified
• Reconstitution Instructions: Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml.

Alternate Names for EDAR Antibody (RM0077-8L53)

• Anhidrotic ectodysplasin receptor 1
• DLED3
• Ectodermal dysplasia receptor
• ectodysplasin 1, anhidrotic receptor
• ectodysplasin A receptor
• Ectodysplasin-A receptor
• ED1R
• ED5
• EDA1R
• EDA3EDA-A1 receptor
• EDA-A1R
• EDAR
• FLJ94390
• HRM1
• mouse, homolog of
• tumor necrosis factor receptor superfamily member EDAR

Background

EDAR (Ectodysplasin A receptor) is a receptor for EDA isoform A1, but not for EDA isoform A2. It has a single transmembrane domain, and shows similarity to 2 separate domains of the tumor necrosis factor (TNF) receptor (TNFR) family. It mediates the activation of NF-kappa-B and JNK and may promote caspase independent cell death. Defects in EDAR are a cause of hypohidrotic ectodermal dysplasia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: EDAR
• Entrez:
  • 10913(Human)