EDAR Products

Description

The EDAR gene encodes a 448 amino acid long, approximately 48 kDA tumor necrosis factor receptor superfamily member EDAR protein that monitors the activation of NF-kappa-B and JNK. It functions as a receptor for EDA isoform 1 but not for isoform 2. EDAR is critical for hair, teeth and other ectodermal derivatives development. EDAR participates in the TNF superfamily pathway, the integrated breast cancer pathway, and the cytokine-cytokine receptor interaction. It is known to interact with genes EDA, TRAF1, TRAF2, TRAF3, as well as EDARADD. Defects in EDAR cause ectodermal dysplasia 10A and 10B. EDAR is linked to hepatitis, immunodeficiency, osteosarcoma, hypotrichosis, tooth agenesis, breast cancer, Clouston syndrome, and ectodermal dysplasia.

Bioinformatics

Entrez	10913 Human
Uniprot	NM_022336 Human NP_071731 Human Q9UNE0 Human
Product By Gene ID	10913
Alternate Names	Anhidrotic ectodysplasin receptor 1 DLED3 Ectodermal dysplasia receptor ectodysplasin 1, anhidrotic receptor ectodysplasin A receptor Ectodysplasin-A receptor ED1R ED5 EDA1R EDA3EDA-A1 receptor EDA-A1R Edar FLJ94390 HRM1 mouse, homolog of tumor necrosis factor receptor superfamily member EDAR

Research Areas for EDAR

Find related products by research area and learn more about each of the different research areas below.

Apoptosis