EDAR Antibody (19E8) [Janelia Fluor® 669]

• Reactivity: Hu
• Applications: WB, ELISA, Flow
• Clone: 19E8
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 669

EDAR Antibody (19E8) [Janelia Fluor® 669] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Recombinant human EDAR (27-448aa) purified from E.coli.
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: EDAR
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP2-42695. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for EDAR Antibody (19E8) [Janelia Fluor® 669]

• Anhidrotic ectodysplasin receptor 1
• DLED3
• Ectodermal dysplasia receptor
• ectodysplasin 1, anhidrotic receptor
• ectodysplasin A receptor
• Ectodysplasin-A receptor
• ED1R
• ED5
• EDA1R
• EDA3EDA-A1 receptor
• EDA-A1R
• EDAR
• FLJ94390
• HRM1
• mouse, homolog of
• tumor necrosis factor receptor superfamily member EDAR

Background

The EDAR gene encodes a 448 amino acid long, approximately 48 kDA tumor necrosis factor receptor superfamily member EDAR protein that monitors the activation of NF-kappa-B and JNK. It functions as a receptor for EDA isoform 1 but not for isoform 2. EDAR is critical for hair, teeth and other ectodermal derivatives development. EDAR participates in the TNF superfamily pathway, the integrated breast cancer pathway, and the cytokine-cytokine receptor interaction. It is known to interact with genes EDA, TRAF1, TRAF2, TRAF3, as well as EDARADD. Defects in EDAR cause ectodermal dysplasia 10A and 10B. EDAR is linked to hepatitis, immunodeficiency, osteosarcoma, hypotrichosis, tooth agenesis, breast cancer, Clouston syndrome, and ectodermal dysplasia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: EDAR