E2F8 Antibody

Product Discontinued

E2F8 Antibody Summary

• Immunogen: Peptide with sequence C-KSIESDRRKINSAPS corresponding to internal region according to NP_078956.2.
• Epitope: internal region
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: E2F8
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:32000
  • Western Blot 1:100 - 1:2000
• Application Notes: WB: Preliminary experiments in human thymus lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for E2F8 Antibody

• E2F family member 8
• E2F transcription factor 8
• E2F-8
• FLJ23311
• transcription factor E2F8

Background

E2F8 is a gene that codes for a protein that is 867 amino acids long, weighs approximately 94 kDa, that is an atypical E2F transcription factor that helps facilitate with various processes including angiogenesis and the polyploidization of specialized cells, especially those in the placenta and liver. Current studies are being done on diseases and disorders related to this gene including hepatocellular carcinoma. E2F8 has also been shown to have interactions with E2F7, EWSR1, and LZTR1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for E2F8 Antibody (NBP1-36952)(2)

Publications using NBP1-36952

• Lui JC, Baron J. Evidence that Igf2 down-regulation in postnatal tissues and up-regulation in malignancies is driven by transcription factor E2f3 Proc Natl Acad Sci U S A 2013-03-25 [PMID: 23530192] (WB, Mouse)
• Li J, Ran C, Li E et al. Synergistic Function of E2F7 and E2F8 Is Essential for Cell Survival and Embryonic Development. Dev Cell. 2008-01-15 [PMID: 18194653]

Bioinformatics

• Gene Symbol: E2F8
• Entrez:
  • 79733(Human)
  • 108961(Mouse)
• Uniprot:
  • NP_078956.2(Human)