DYRK1A Antibody [Alexa Fluor® 405]

• Reactivity: Hu, Rt
• Applications: WB, IHC, IP
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 405

DYRK1A Antibody [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human DYRK1A
  Arg438-Thr511
  Accession # Q13627
• Specificity: Detects human and rat DYRK1A in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunoprecipitation
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DYRK1A Antibody [Alexa Fluor® 405]

• dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
• DYRK1
• DYRK1A
• MNBEC 2.7.110EC 2.7.12
• MNBH

Background

DYRK1A (Dual-specificity tyrosine [Y] phosphorylation regulated kinase 1A; also hMNB) is a member of the MNB/DYRK subfamily, CMGC Ser/Thr protein kinase family of enzymes. DYRK1A is ubiquitously expressed and shows dual substrate specificity. Autophosphorylation on Tyr321 leads to self-activation, while target proteins are Ser/Thr phosphorylated. Targets include APP, Tau, STAT3, and Cyclin L2. Human DYRK1A is 763 amino acids (aa) in length. It contains two NLSs (aa 69‑105 and 109-150), a kinase catalytic domain (aa 159-479), and C-terminal poly-Ser and poly-His regions. DYRK1A activity has been implicated in neuronal development and Down syndrome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.